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T-448
$550 – $4,800
Products Details
Product Description
– T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].
Web ID
– HY-122635A
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H20N4OS.1/2C4H4O4
References
– [1]Matsuda S, et al. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22.
CAS Number
– 1597426-53-3
Molecular Weight
– 386.50
Compound Purity
– 98.86
SMILES
– O=C(NC1=NN=C(C)S1)C2=CC=CC([C@H]3[C@H](NC4CCC4)C3)=C2.O=C(O)/C=C/C(O)=O.[1/2]
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 16.67 mg/mL (ultrasonic)
Target
– Histone Demethylase
Isoform
– KDM1/LSD1
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
