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Products Details
Product Description
– YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes[1][2].
Web ID
– HY-122613
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C23H24O6
References
– [1]Nakada N. Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2. Pharm Res. 2017 Apr;34(4):874-886.|[2]Ikegai K, et, al. Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: discovery of YM543. Bioorg Med Chem. 2013 Jul 1;21(13):3934-48.
CAS Number
– 655237-16-4
Molecular Weight
– 396.43
SMILES
– O[C@H]([C@H]1O)[C@@](C2=CC(CC3=CC4=CC=CC=CC4=C3)=CC=C2O)([H])O[C@@H]([C@H]1O)CO
Clinical Information
– Phase 2
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– SGLT
Isoform
– SGLT2
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
