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Dinactin
$996
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Products Details
Product Description
– Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain[1].
Web ID
– HY-121333
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C42H68O12
References
– [1]Aehtesham Hussain, et al. Identification of dinactin, a macrolide antibiotic, as a natural product-based small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Cancer Chemother Pharmacol. 2019 Sep;84(3):551-559.
CAS Number
– 20261-85-2
Molecular Weight
– 764.98
SMILES
– CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3CC)=O)C)CC5)C)=O)C)([H])CC4
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease; Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Wnt;β-catenin
Pathway
– Anti-infection;Stem Cell/Wnt
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
