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Products Details
Product Description
– Navafenterol (AZD-8871) saccharinate is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol saccharinate can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile[1].
Web ID
– HY-120802A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C45H47N7O9S3
References
– [1]Mònica Aparici, et al. Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/ β 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile. J Pharmacol Exp Ther. 2019 Jul;370(1):127-136.
CAS Number
– 1648550-37-1
Molecular Weight
– 926.09
SMILES
– O=C(C(O)(C1=CC=CS1)C2=CC=CS2)O[C@H]3CC[C@@H](CC3)N(C)CCCN4N=NC5=CC(CNC[C@H](O)C6=CC=C(C7=C6C=CC(N7)=O)O)=CC=C54.O=S8(C9=CC=CC=C9C(N8)=O)=O
Clinical Information
– Phase 2
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;mAChR
Isoform
– mAChR3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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