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Vatalanib (dihydrochloride)
$38 – $132
Products Details
Product Description
– Vatalanib dihydrochloride (PTK787 dihydrochloride) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.
Web ID
– HY-12018
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H17Cl3N4
Citations
– Bioact Mater. 2 January 2022.|Br J Pharmacol. 2019 Sep;176(17):3143-3160. |Evid-Based Compl Alt. 2021 Apr 27.|Kitazato Graduate School of Pharmaceutical Sciences. Kitasato University. 2017.|Oncol Rep. 2016 Mar;35(3):1297-308.|Oxid Med Cell Longev. 18 Jul 2022.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|Ulm University. 2023 Mar 21.|Drug Metab Pharmacokinet. 2017 Jun;32(3):179-188. |J Microbiol Biotechnol. 2015 Aug;25(8):1227-33. |J Pharm Anal. 2023 Sep 11.|Patent. US20170349880A1.
References
– [1]Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011, 18(2), 589-596.|[2]Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000, 60(8|[3]Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016 Mar;35(3):1297-308.
CAS Number
– 212141-51-0
Molecular Weight
– 419.73
Compound Purity
– 99.91
SMILES
– ClC1=CC=C(C=C1)NC2=NN=C(C3=C2C=CC=C3)CC4=CC=NC=C4.[H]Cl.[H]Cl
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 50 mg/mL (ultrasonic)
Target
– Apoptosis;VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
