Download Files:
TP0427736 (hydrochloride)
$200 – $1,650
Products Details
Product Description
– TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1].
Web ID
– HY-118528A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C14H11ClN4S2
References
– [1]Takumi Naruse, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 May;69(3):485-491.
CAS Number
– 2459963-17-6
Molecular Weight
– 334.85
Compound Purity
– 98.28
SMILES
– CC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)N=CN2)=N1.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– TGF-β Receptor
Pathway
– TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
