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Products Details
Product Description
– TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].
Web ID
– HY-118528
Shipping
– Room temperature
Molecular Formula
– C14H10N4S2
References
– [1]Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491.
CAS Number
– 864374-00-5
Molecular Weight
– 298.39
SMILES
– CC1=CSC(C2=C(NC=N2)C3=CC=C4N=CSC4=C3)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– TGF-β Receptor
Pathway
– TGF-beta/Smad
Product type
– Reference compound
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