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CM-579 trihydrochloride
$250 – $1,500
Products Details
Product Description
– CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
Web ID
– HY-117421A
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H43Cl3N4O3
References
– [1]San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.
Molecular Weight
– 602.04
Compound Purity
– 98.03
SMILES
– CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 37.5 mg/mL (ultrasonic)
Target
– DNA Methyltransferase;Histone Methyltransferase
Isoform
– DNA Methyltransferase;DNMT1;DNMT3
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
