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Products Details
Product Description
– CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
Web ID
– HY-117421
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H40N4O3
References
– [1]San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.
CAS Number
– 1846570-40-8
Molecular Weight
– 492.65
SMILES
– CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA Methyltransferase;Histone Methyltransferase
Isoform
– DNA Methyltransferase;DNMT1;DNMT3;EHMT2/G9a/KMT1C
Pathway
– Epigenetics
Product type
– Reference compound
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