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Products Details
Product Description
– UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].
Web ID
– HY-117233
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C33H33ClN4O9
References
– [1]Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201.|[2]Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692.
CAS Number
– 1500080-17-0
Molecular Weight
– 665.09
SMILES
– OC(CC[C@@H](C(OC)=O)NC([C@H](CC(O)=O)NC([C@H](CC1=CC2=C(C=CC=C2)C=C1)NC(CC3=CC4=CC(Cl)=CC=C4N3)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Wnt;β-catenin
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
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