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Products Details
Product Description
– Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (Kis of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines[1].
Web ID
– HY-115999
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H22BrN5O5S2
References
– [1]Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. Eur J Med Chem. 2022;228:114004.
CAS Number
– 2883451-38-3
Molecular Weight
– 640.53
SMILES
– COC1=CC=C(C(C2=NC(SCC(C3=CC=C(C=C3)Br)=O)=NC(NC4=CC=C(C=C4)S(N)(=O)=O)=C2C#N)=C1)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA â…¡
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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