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Products Details
Product Description
– VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2[1].
Web ID
– HY-114310
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H51N3O2
References
– [1]Wang C, et al. Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer. Eur J Med Chem. 2019 Feb 1;163:787-803.
CAS Number
– 2269494-43-9
Molecular Weight
– 509.77
SMILES
– O=C(C1=CC(C(CC)(C2=CC=C(/C=C/C(O)(CC)CC)C(C)=C2)CC)=CN1CC)NCCN(CC)CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;VD/VDR
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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