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Products Details
Product Description
– ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice[1].
Web ID
– HY-113889
Shipping
– Room temperature
Molecular Formula
– C29H32O3
References
– [1]Claudia Lanari, et al. Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 May 3;19(3):R35-50.|[2]C A Sartorius, et al. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 5;268(13):9262-6.
CAS Number
– 105114-63-4
Molecular Weight
– 428.56
SMILES
– C[C@@]12[C@](CC[C@@]2(O)C#CC)([H])[C@@]3([H])C([C@@H](C4=CC=C(C=C4)C(C)=O)C1)=C5C(CC3)=CC(CC5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Progesterone Receptor
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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