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Products Details
Product Description
– CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration[1].
Web ID
– HY-112742
Shipping
– Room temperature
Molecular Formula
– C24H19F3O4
References
– [1]Showell HJ, et al. The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543. J Pharmacol Exp Ther. 1998 Jun;285(3):946-54.
CAS Number
– 204981-48-6
Molecular Weight
– 428.40
SMILES
– O=C(O)C1=CC=C(C(F)(F)F)C=C1C2=CC=C3[C@H](O)[C@@H](CC4=CC=CC=C4)COC3=C2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Leukotriene Receptor
Isoform
– LTB4
Pathway
– GPCR/G Protein
Product type
– Reference compound
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