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AMG 333
$90 – $500
Products Details
Product Description
– AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.
Web ID
– HY-112703
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H12F5N3O4
References
– [1]Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201.
CAS Number
– 1416799-28-4
Molecular Weight
– 453.32
Compound Purity
– 99.82
SMILES
– FC1=CC=CN=C1[C@H](C2=CC(F)=C(OC(F)(F)F)C=C2)NC(C3=NC=C(C(O)=O)C=C3)=O
Clinical Information
– Phase 1
Research Area
– Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : ≥ 125 mg/mL
Target
– TRP Channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
