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Products Details
Product Description
– PI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3Kγ inhibitor with a Ki of 4 nM[1].
Web ID
– HY-112286
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H18F3N5O3
References
– [1]Come JH, et al. Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J Med Chem. 2018 Jun 28;61(12):5245-5256.
CAS Number
– 1315538-79-4
Molecular Weight
– 433.38
SMILES
– O=C1N(C2=CN(CC(F)(F)F)N=C2)[C@H](C)C3=NC(C4=CC(OC)=C(OC)N=C4)=CC=C31
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PI3K
Isoform
– PI3Kγ
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
