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Products Details
Product Description
– YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition[1].
Web ID
– HY-146806
Shipping
– Room temperature
Molecular Formula
– C37H38Cl2F2N4O4
References
– [1]Zhang S, et al. Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells. J Med Chem. 2022 Apr 28;65(8):6207-6230.
CAS Number
– 2771313-42-7
Molecular Weight
– 711.62
SMILES
– FC(C(Cl)=CC=C1)=C1[C@@H]([C@@H](N[C@H]2CC(C)(C)C)C(NC3=CC=C(C=C3OC)C(O)=O)=O)[C@]2(C4=CC=C(Cl)C=C4F)CNCC5=CC=NC=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
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