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Products Details
Product Description
– WY-135 is an ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor.
Web ID
– HY-111416
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H34ClN9O3S
References
– [1]Wang Y, et al. Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R. Eur J Med Chem. 2018 Jan 1;143:123-136.
CAS Number
– 2163060-83-9
Molecular Weight
– 612.15
SMILES
– CC(C)S(C1=C(NC2=NC(NC3=C(OC)C=C(N4C=C(CN5CCN(C)CC5)N=N4)C=C3)=NC=C2Cl)C=CC=C1)(=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK);ROS Kinase
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
