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Products Details
Product Description
– BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis, cell cycle arrest and DNA damage. BCL6-IN-10 inhibits AML cell proliferation (IC50s: 0.91, 1.63, 1.026, 7.42, 0.87, 0.85μM for OCl-AML3, THP1, MOLM13, HL60, KG1, NB4 cell respectively)[1].
Web ID
– HY-149522
Shipping
– Room temperature
Molecular Formula
– C21H20BrN7O3
References
– [1]Zhang L, et al. A small molecule BCL6 inhibitor as chemosensitizers in acute myeloid leukemia. Biomed Pharmacother. 2023 Oct;166:115358.
Molecular Weight
– 498.33
SMILES
– O=C(O1)C=CC2=C1C=CC(NC3=CC(N4CCCC(NC(CBr)=O)C4)=NC5=NC=NN53)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
