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Products Details
Product Description
– VEGFR-2/c-Met-IN-2 (compound 3e) is a VEGFR-2/c-Met inhibitor, with IC50 values of 83 and 48 nM, respectively. VEGFR-2/c-Met-IN-2 exhibits cytotoxic activity against HCT-116 cell line (IC50: 3.403 µM)[1].
Web ID
– HY-149675
Shipping
– Room temperature
Molecular Formula
– C22H15ClN4O3S
References
– [1]Hassan A, et al. Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation. Sci Rep. 2023 Oct 30;13(1):18567.
Molecular Weight
– 450.90
SMILES
– O=C(NC(NC1=CC=C(Cl)C=C1)=S)C2=CC=C(N3C(NC4=C(C=CC=C4)C3=O)=O)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– c-Met/HGFR;VEGFR
Isoform
– Met;VEGFR2/KDR/Flk-1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
