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Products Details
Product Description
– UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM[1].
Web ID
– HY-149988
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C62H71F3N14O10
References
– [1]Silvestri AP, et al. DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor. ACS Med Chem Lett. 2023 May 5;14(6):820-826.
Molecular Weight
– 1229.31
SMILES
– O=C(N[C@H](C(NCC(NC[C@H](C(N[C@@H](CC1=CC(C(F)(F)F)=CC=C1)C(N[C@@H]2CN(C(C3=CC=CC=C3)=O)[C@H](C(N[C@@H](C(N)=O)CC(N=N4)=CN4CC5=O)=O)C2)=O)=O)C(C)C)=O)=O)CC6=CC=CC=C6)[C@@H](NC([C@@H](N5)C(C)C)=O)CC7=CNC8=C7C=CC=C8
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
