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Tracazolate (hydrochloride)
$74 – $400
Products Details
Product Description
– Tracazolate (ICI 136753) hydrochloride is a potent GABAA receptor modulator. Tracazolate hydrochloride has selectivity for β3 and potentiates α1β1γ2s (EC50=13.2 μM), α1β3γ2 (EC50=1.5 μM). Tracazolate hydrochloride has the potency (EC50) determined by the nature of the third subunit (γ1-3, δ, ε) within the receptor complex. Tracazolate hydrochloride possesses anxiolytic and anticonvulsant activity[1][2].
Web ID
– HY-B1803A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C16H25ClN4O2
References
– [1]Sally-Anne Thompson, et al. Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Mol Pharmacol. 2002 Apr;61(4):861-9.|[2]N Zheleznova, et al. alpha1beta2delta, a silent GABA<sub>A</sub> receptor: recruitment by tracazolate and neurosteroids. Br J Pharmacol. 2008 Mar;153(5):1062-71.
CAS Number
– 1135210-68-2
Molecular Weight
– 340.85
Compound Purity
– 99.03
SMILES
– O=C(C1=C(C)N=C(N(CC)N=C2)C2=C1NCCCC)OCC.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– GABA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
