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Terbinafine
$66 – $117
Products Details
Product Description
– Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-17395A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H25N
Citations
– Adv Healthc Mater. 2023 May 20;e2300018.|Cancer Commun (Lond). 2021 Jul 16.|Infect Drug Resist. 2022: 7459-7473.|Research Square Preprint. 2023 Sep 26.|Cell Death Dis. 2021 May 13;12(5):482.
References
– [1]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-7.|[2]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-7.|[3]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82.
CAS Number
– 91161-71-6
Molecular Weight
– 291.43
Compound Purity
– 99.91
SMILES
– CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1
Clinical Information
– Launched
Research Area
– Infection
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Antibiotic;Bacterial;Fungal
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
