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TCL053
$150 – $1,550
Products Details
Product Description
– TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle[1][2].
Web ID
– HY-147332
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C53H95NO8
References
– [1]Kenjo E, et al. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021 Dec 8;12(1):7101.|[2]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654819/
CAS Number
– 2361162-70-9
Molecular Weight
– 874.32
Compound Purity
– 98.0
SMILES
– CN(C)CCCC(OCC(COC(CCCCCCC/C=CCCCC)=O)(COC(CCCCCCC/C=CCCCC)=O)COC(CCCCCCC/C=CCCCC)=O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Liposome
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
