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SPC5001
$890 – $3,400
Products Details
Product Description
– SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′[1].
Web ID
– HY-148687
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– N/A
References
Р[1]Nieskens TTG, et, al. Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip. Arch Toxicol. 2021 Jun;95(6):2123-2136. |[2]Lindholm MW, Elm̩n J, Fisker N, et al. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates. Mol Ther. 2012;20(2):376-381.
Molecular Weight
– 4689.85
Compound Purity
– 93.97
SMILES
– [SPC5001]
Clinical Information
– Phase 1
Research Area
– Cardiovascular Disease
Solubility
– H2O : ≥ 100 mg/mL
Target
– Others
Pathway
– Others
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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