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Products Details
Product Description
– SIRT6-IN-3 (compound 8a) is a selective inhibitor of SIRT6 (IC50=7.49 μM). SIRT6-IN-3 inhibits pancreatic ductal adenocarcinoma (PDAC) cells proliferation and induces apoptosis. SIRT6-IN-3 increases the sensitivity of cancer cells to gemcitabine (HY-17026) via blocking the DNA damage repair pathway. SIRT6-IN-3 is used in pancreatic cancer research[1].
Web ID
– HY-156027
Shipping
– Room temperature
Molecular Formula
– C21H30Br3ClN6S
References
– [1]Song N, et al. Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine. Cell Death Dis. 2023 Aug 4;14(8):499.
Molecular Weight
– 673.73
SMILES
– BrC1=C(Br)NC(C2=NC=CC3=C2N=CN3CCCCCCS/C(N(C)C)=[N+](C)C)=C1.Cl.[Br-]
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Akt;ERK;HDAC;mTOR;Ribosomal S6 Kinase (RSK);Sirtuin
Isoform
– HDAC3;HDAC6;HDAC8;SIRT1;SIRT2;SIRT6
Pathway
– Cell Cycle/DNA Damage;Epigenetics;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
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