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Selinexor
$90 – $960
Products Details
Product Description
– Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable and selective CRM1 inhibitor[1][2].
Web ID
– HY-17536
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H11F6N7O
References
– [1]Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013 Apr;161(1):117-27.|[2]Tai YT, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014 Jan;28(1):155-65.
CAS Number
– 1393477-72-9
Molecular Weight
– 443.31
Compound Purity
– 99.85
SMILES
– O=C(NNC1=NC=CN=C1)/C=CN2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : ≥ 48 mg/mL
Target
– CRM1
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
