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Products Details
Product Description
– S6K2-IN-1 (Compound 2) is a S6K2 inhibitor (IC50: 22 nM). S6K2-IN-1 also inhibits FGFR4 (IC50: 216 nM). S6K2-IN-1 has acceptable stability in mouse liver microsomes[1].
Web ID
– HY-156672
Shipping
– Room temperature
Molecular Formula
– C24H23ClF3N9O2
References
– [1]Gerstenecker S, et al. Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2). Cancers (Basel). 2021 Oct 13;13(20):5133.
Molecular Weight
– 561.95
SMILES
– ClC1=CC=C([N+]([O-])=O)C(NC2=NC(N3CCN(CC4=NC5=C(C=CC(C(F)(F)F)=C5)N4)CC3)=C(CC)C=N2)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
