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Rolipram
$35 – $108
Products Details
Product Description
– Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Web ID
– HY-16900
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H21NO3
References
– [1]Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.|[2]MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr|[3]Shalaby AM, et al. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
CAS Number
– 61413-54-5
Molecular Weight
– 275.34
Compound Purity
– 99.58
SMILES
– O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Clinical Information
– Phase 2
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : ≥ 41 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Bacterial;HIV;Phosphodiesterase (PDE)
Isoform
– PDE4
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
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