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Products Details
Product Description
– RO 2468 is a potent, orally active and selective p53-MDM2 inhibitor. RO 2468 has anti-proliferative active. RO 2468 suppresses c growth in SJSA1 osteosarcoma models without obvious toxicity[1].
Web ID
– HY-12579
Shipping
– Room temperature
Molecular Formula
– C30H30Cl2FN5O4
References
– [1]Zhang Z, et, al. Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.
CAS Number
– 1360821-21-1
Molecular Weight
– 614.49
SMILES
– COC1=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C5=CN=C(Cl)C=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=CC(C(N)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
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