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Products Details
Product Description
– PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].
Web ID
– HY-103132
Shipping
– Room temperature
Molecular Formula
– C24H31N3O3
References
– [1]Cutrer FM, et al. Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology. 1999 Jul;38(7):1043-53.|[2]Winters BL, et al. Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission. Br J Pharmacol. 2020 Aug;177(16):3730-3743.
CAS Number
– 187665-60-7
Molecular Weight
– 409.52
SMILES
– O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(OC)C=C4)CC3)=C1)NC
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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