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Pifithrin-α (hydrobromide)
$66 – $356
Products Details
Product Description
– Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
Web ID
– HY-15484
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H19BrN2OS
References
– [1]Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314(2):603-10.|[2]Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61.|[3]Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12(2):198-209.
CAS Number
– 63208-82-2
Molecular Weight
– 367.30386
Compound Purity
– 98.05
SMILES
– N=C1SC2=C(CCCC2)N1CC(C3=CC=C(C)C=C3)=O.[H]Br
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 50 mg/mL|H2O : 1.25 mg/mL (ultrasonic)
Target
– Apoptosis;Aryl Hydrocarbon Receptor;Ferroptosis;MDM-2/p53
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
