– Phosphoglycerate kinase (PGK) is a glycolytic enzyme that catalyzes the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP, resulting in the production of 3-phosphoglycerate (3-PG) and ATP. This enzyme not only plays a crucial role in the glycolysis pathway but also participates in gluconeogenesis by catalyzing the reverse reaction to produce 1,3-BPGA and ADP. Phosphoglycerate kinase is essential for energy metabolism, nucleic acid interactions, tumor progression, cell death, and virus replication, among other processes [1].