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PD-118057
$120 – $1,920
Products Details
Product Description
– PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability[1][2].
Web ID
– HY-108594
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C21H17Cl2NO2
References
– [1]Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8(6):e65481.|[2]Yeung SY, et al. Pharmacological and biophysical isolation of K+ currents encoded by ether-Ã -go-go-related genes in murine hepatic portal vein smooth muscle cells. Am J Physiol Cell Physiol. 2007 Jan;292(1):C468-76. |[3]Meng J, et al. Effect of PD-118057attenuates hypokalaemia or drug-induced prolongation of action potential duration in guinea pig ventricular myocytes. 2014,29(05):536-538.
CAS Number
– 313674-97-4
Molecular Weight
– 386.27
Compound Purity
– 99.0
SMILES
– O=C(O)C1=CC=CC=C1NC2=CC=C(CCC3=CC=C(Cl)C(Cl)=C3)C=C2
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
