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OTSSP167
$100 – $250
Products Details
Product Description
– OTSSP167 (OTS167) is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.
Web ID
– HY-15512
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H28Cl2N4O2
Citations
– Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11. |Blood Cancer J. 2019 Nov 18;9(12):87.|Int J Oncol. 2022 Jul;61(1):89.|Mol Cancer. 2014 May 4;13:100.|Oncotarget. 2016 Feb 2;7(5):6266-80. |Oncotarget. 2017 Dec 20;9(2):2591-2602. |Patent. US20160291017A1.|PLoS One. 2017 Feb 24;12(2):e0172832. |Sci Rep. 2017 Feb 14;7:42502.|Clin Cancer Res. 2018 Nov 15;24(22):5645-5657. |Elife. 2017 Mar 24;6:e24179.|Elife. 2018 Feb 8;7:e32838. |EMBO Mol Med. 2018 Mar;10(3). pii: e8274.|Free Radic Biol Med. 2021 Jun 15;S0891-5849(21)00377-4.|Gynecol Oncol. 2017 Apr;145(1):159-166.|Harvard Medical School LINCS LIBRARY|Neuro Oncol. 2020 Jan 11;22(1):58-69.
References
– [1]Li S, et al. Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer. Oncotarget. 2016 Feb 2;7(5):6266-80.|[2]Cho YS, et al. The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11.|[3]Ji W, et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11(4):e0153518.|[4]Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21.
CAS Number
– 1431697-89-0
Molecular Weight
– 487.42
Compound Purity
– 99.70
SMILES
– ClC1=CC(C2=CC=C(N=CC(C(C)=O)=C3N[C@H]4CC[C@H](CN(C)C)CC4)C3=N2)=CC(Cl)=C1O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 2.5 mg/mL (ultrasonic;warming;adjust pH to 4 with 1M HCl;heat to 60°C)
Target
– MELK
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
