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Ondansetron (hydrochloride dihydrate)
$66 – $251
Products Details
Product Description
– Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery[1][2].
Web ID
– HY-B0002A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H24ClN3O3
Citations
– Eur J Pharm Sci. 2023 May 22;106475.|Int J Pharm. 2015 Dec 30;496(1):33-41.|Patent. US20170319486A1.|Journal of Radiation Research and Applied Sciences. 2023 Dec, 16(4), 100682.|Prog Neuropsychopharmacol Biol Psychiatry. 2022 Nov 30;110689.|SSRN. 2023 Srep 5.
References
– [1]Yamamoto K, et al. Ondansetron, dexamethasone and an NK1 antagonist block radiation sickness in mice. Pharmacol Biochem Behav. 2005 Sep;82(1):24-9. |[2]Wilde MI, et al. Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications. Drugs. 1996 Nov;52(5):773-94.
CAS Number
– 103639-04-9
Molecular Weight
– 365.85
Compound Purity
– 99.03
SMILES
– O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl.O.O
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)
Target
– 5-HT Receptor
Isoform
– 5-HT3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
