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Ondansetron
$38 – $84
Products Details
Product Description
– Ondansetron (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity[1][2][3][4][5][6][7][8].
Web ID
– HY-B0002B
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H19N3O
Citations
– Journal of Radiation Research and Applied Sciences. 2023 Dec, 16(4), 100682.|Prog Neuropsychopharmacol Biol Psychiatry. 2022 Nov 30;110689.|SSRN. 2023 Srep 5.|Eur J Pharm Sci. 2023 May 22;106475.|Int J Pharm. 2015 Dec 30;496(1):33-41.|Patent. US20170319486A1.
References
– [1]Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.|[2]Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.|[3]Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.|[4]Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.|[5]Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.|[6]Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.|[7]Xin Wang, et al. Effectiveness of Olanzapine Combined with Ondansetron in Prevention of Chemotherapy-Induced Nausea and Vomiting of Non-small Cell Lung Cancer. Cell Biochem Biophys. 2015 Jun;72(2):471-3.|[8]Azadeh Motavallian-Naeini, et al. Anti-inflammatory effect of ondansetron through 5-HT3 receptors on TNBS-induced colitis in rat. EXCLI J2012 Feb 22:11:30-44. eCollection 2012.
CAS Number
– 99614-02-5
Molecular Weight
– 293.36
Compound Purity
– 99.46
SMILES
– O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 10 mg/mL (ultrasonic)|H2O : ≥ mg/mL
Target
– 5-HT Receptor
Isoform
– 5-HT3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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