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NTP42
$175 – $1,125
Products Details
Product Description
– NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46619[1]. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH)[2].
Web ID
– HY-129851
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H23F2N3O5S
References
– [1]B. Therese KINSELLA, et al. Thromboxane receptor antagonists. WO2016203314A1.|[2]Eamon Mulvaney, et al. NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
CAS Number
– 2055599-51-2
Molecular Weight
– 515.53
Compound Purity
– 98.02
SMILES
– O=S(C1=CC(C#N)=CC=C1OC2=CC(C3=CC=C(OC(F)F)C=C3)=CC=C2)(NC(NC(C)(C)C)=O)=O
Clinical Information
– Phase 1
Research Area
– Cardiovascular Disease
Solubility
– DMSO : 31.25 mg/mL (ultrasonic)
Target
– Prostaglandin Receptor
Isoform
– TXA2/TP
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
