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Products Details
Product Description
– Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease[1].
Web ID
– HY-150563
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C25H27FN2O3
References
– [1]Yang Z, et al. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer’s disease. Bioorg Med Chem. 2020 Apr 1;28(7):115374.
CAS Number
– 2361384-14-5
Molecular Weight
– 422.49
SMILES
– CC(C1=CC=C(C2=CC=C(NCC3=CC(N(C)C)=CC=C3O)C=C2)C(F)=C1)C(OC)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β;Monoamine Oxidase
Isoform
– MAO-B
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
