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Product Description
– N-Salicyloyltryptamine acts on voltage-dependent Na+, Ca2+, and K+ ion channels inhibitor. N-Salicyloyltryptamine inhibits K+ currents with an IC50 value of 34.6 μM (Ito). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect[1]-[5].
Web ID
– HY-147377
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H16N2O2
References
Р[1]Gasparotto J, et al Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages. Cell Biol Toxicol. 2013 Jun;29(3):175-87. |[2]Ara̼jo DA, et al. N-salicyloyltryptamine, a new anticonvulsant drug, acts on voltage-dependent Na+, Ca2+, and K+ ion channels. Br J Pharmacol. 2003 Dec;140(7):1331-9. |[3]Veras RC, et al. N-Salicyloyltryptamine, an N-Benzoyltryptamine Analogue, Induces Vasorelaxation through Activation of the NO/sGC Pathway and Reduction of Calcium Influx. Molecules. 2018 Jan 28;23(2):253. |[4]Oliveira FA, et al. Anticonvulsant properties of N-salicyloyltryptamine in mice. Pharmacol Biochem Behav. 2001 Feb;68(2):199-202. |[5]Quintans LJ Jr, et al. Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach. J Biomed Biotechnol. 2010;2010:230745.
CAS Number
– 31384-98-2
Molecular Weight
– 280.32
SMILES
– OC1=C(C(NCCC2=CNC3=C2C=CC=C3)=O)C=CC=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;ERK;Guanylate Cyclase;NF-κB;Potassium Channel
Isoform
– L-type calcium channel
Pathway
– GPCR/G Protein;MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Neuronal Signaling;NF-κB;Stem Cell/Wnt
Product type
– Reference compound
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