Products Details

Product Description

– MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1].

Web ID

– HY-149087

Shipping

– Room temperature

Molecular Formula

– C21H24N4O3

References

– [1]Lv L, et al. Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities. Eur J Med Chem. 2023 Apr 6;254:115346.

CAS Number

– 1044870-65-6

Molecular Weight

– 380.44

SMILES

– COC1=CC(OC)=C2C(NC(C3=CC=C(C=C3)N4CCN(CC4)C)=NC2=C1)=O

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– CCR;Cholinesterase (ChE);Interleukin Related;JNK;NF-κB;NO Synthase;NOD-like Receptor (NLR);TNF Receptor

Isoform

– AChE;BChE;IL-1;IL-6;JNK;NF-κB;NLRP3

Pathway

– Apoptosis;GPCR/G Protein;Immunology/Inflammation;MAPK/ERK Pathway;Neuronal Signaling;NF-κB

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

My Cart
Close Wishlist
Close Recently Viewed
Categories

Please fill out this form to request the file. We will send it to your Email address shortly. Thanks.

Please enable JavaScript in your browser to complete this form.

=

Please fill out this form to request the pricing.
We will send it to your email address shortly.
Thanks.

Please enable JavaScript in your browser to complete this form.

=