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MR2938
Products Details
Product Description
– MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1].
Web ID
– HY-149087
Shipping
– Room temperature
Molecular Formula
– C21H24N4O3
References
– [1]Lv L, et al. Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities. Eur J Med Chem. 2023 Apr 6;254:115346.
CAS Number
– 1044870-65-6
Molecular Weight
– 380.44
SMILES
– COC1=CC(OC)=C2C(NC(C3=CC=C(C=C3)N4CCN(CC4)C)=NC2=C1)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– CCR;Cholinesterase (ChE);Interleukin Related;JNK;NF-κB;NO Synthase;NOD-like Receptor (NLR);TNF Receptor
Isoform
– AChE;BChE;IL-1;IL-6;JNK;NF-κB;NLRP3
Pathway
– Apoptosis;GPCR/G Protein;Immunology/Inflammation;MAPK/ERK Pathway;Neuronal Signaling;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.