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Products Details
Product Description
– ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases[1].
Web ID
– HY-14441
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C15H21ClN2O3
References
– [1] Cachard-Chastel M, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007;150(7):883-892.|[2]Yang D, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997;40(4):608-621.|[3]De Ponti F, et al. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001;13(6):543-553.
CAS Number
– 148868-55-7
Molecular Weight
– 312.79
SMILES
– O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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