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Products Details
Product Description
– MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines[1].
Web ID
– HY-146884
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H16ClF2N5O2
References
– [1]Wang MS, et al. Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold. Eur J Med Chem. 2020 Jan 1;185:111803.
CAS Number
– 1446324-02-2
Molecular Weight
– 491.88
SMILES
– NC1=NC=CC(OC2=C(C=C(C=C2)NC3=C4C(C(C5=CC=C(C=C5)F)=CNC4=CC=N3)=O)F)=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– c-Met/HGFR;VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
