Download Files:
Products Details
Product Description
– Menin-MLL inhibitor 29 (Compound C1) is a Menin-MLL PPI inhibitor. Menin-MLL inhibitor 29 binds to Menin with a KD value of 138 nM, and inhibits the binding of Menin to MBM1 (Menin-binding motif 1) with an IC50 value of 46 nM. Menin-MLL inhibitor 29 inhibits HepG2 and Hep3B hepatoma cell proliferation (IC50s: 0.31 μM and 0.71 μM). Menin-MLL inhibitor 29 inhibits tumor growth[1].
Web ID
– HY-156130
Shipping
– Room temperature
Molecular Formula
– C36H26Br2F6N4PRh
References
– [1]Zhong HJ, et al. Development of an orally bioavailable selective inhibitor of the menin-MLL. Genes Dis. 2022 Oct 18;10(5):1735-1738.
Molecular Weight
– 922.30
SMILES
– BrC1=C[C-]([Rh+3]23([C-]4=CC(Br)=CC=C4C5=[N]2C=CC=C5)([N]6=CC=CC7=C6C8=C(C(C)=C7C)C=CC=[N]38)[N]9=C%10C=CC=C9)=C%10C=C1.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
