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Products Details
Product Description
– LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1][2].
Web ID
– HY-103105
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C32H40ClN3O
References
– [1]Sugiyama Y, et, al. Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice. J Reprod Dev. 2019 Dec 18;65(6):541-550. |[2]Marcello Leopoldo, et al. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50(17):4214-21.
CAS Number
– 1185136-22-4
Molecular Weight
– 518.13
SMILES
– O=C(NC1CCCC2=C1C=CC=C2)CCCCCN3CCN(C4=CC=CC=C4C5=CC=CC=C5)CC3.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Isoform
– 5-HT1 Receptor;5-HT2 Receptor;5-HT7 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
