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LB-100
$168 – $750
Products Details
Product Description
– LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells[1][2][3].
Web ID
– HY-18597
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H20N2O4
References
– [1]Bai X, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis. Cancer Lett. 2014 Oct 7. pii: S0304-3835(14)00589-8.|[2]Fu QH, et al. LB-100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. Tumour Biol. 2016 Jun;37(6):7277-8|[3]Bai XL, et al. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13(8):2062-72.
CAS Number
– 1632032-53-1
Molecular Weight
– 268.31
Compound Purity
– 98.0
SMILES
– O=C(C1[C@@H](O2)CC[C@@H]2C1C(N3CCN(C)CC3)=O)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMF : 1 mg/mL (ultrasonic)|DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : ≥ 48 mg/mL
Target
– Phosphatase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
