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L-364,373
$65 – $610
Products Details
Product Description
– L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].
Web ID
– HY-108591
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H20FN3O
References
– [1]Jow F, et al. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev Technol. 2006 Aug;4(4):443-50.
CAS Number
– 103342-82-1
Molecular Weight
– 397.44
Compound Purity
– 99.67
SMILES
– O=C1N(C)C2=CC=CC=C2C(C3=CC=CC=C3F)=N[C@@H]1CC4=CNC5=C4C=CC=C5
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
