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GPI-1046
$70 – $650
Products Details
Product Description
– GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2]. GPI-1046 improves HIV-associated injury of peripheral nerves[3].
Web ID
– HY-124619
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C20H28N2O4
References
– [1]Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35.|[2]Eberling JL, et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol. 2002 Dec;178(2):236-42.|[3]Scott Letendre, et al. Neurologic Complications of HIV Disease and Their Treatment. Top HIV Med. Apr-May 2007;15(2):32-9.
CAS Number
– 186452-09-5
Molecular Weight
– 360.45
Compound Purity
– 99.74
SMILES
– O=C(OCCCC1=CC=CN=C1)[C@H]2N(C(C(C(C)(C)CC)=O)=O)CCC2
Clinical Information
– No Development Reported
Research Area
– Infection; Neurological Disease
Solubility
– DMSO : ≥ 100 mg/mL
Target
– FKBP;HIV
Isoform
– GlyT1
Pathway
– Anti-infection;Apoptosis;Autophagy;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
