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Products Details
Product Description
– FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC50 of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC[1].
Web ID
– HY-144759
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H22ClF3N4O4
References
– [1]Chaudhary CL, et al. 6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation. J Enzyme Inhib Med Chem. 2022 Dec;37(1):844-856.
Molecular Weight
– 522.90
SMILES
– C=CC(NC1=CC(F)=CC(Cl)=C1NC2=NC(C)=C(C(C)=N2)OCC3=C(C(OC)=CC(OC)=C3F)F)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Isoform
– FGFR4
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
