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Products Details
Product Description
– FGFR4-IN-12 (Compound A34) is a potent inhibitor of FGFR4. FGFR4-IN-12 exhibits improved FGFR4 inhibitory capability and selectivity and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines. FGFR4-IN-12 has the potential for the research of cancer diseases[1]. FGFR4-IN-12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-147793
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C34H32Cl2N4O6
References
– [1]Zhang X, et al. Discovery of 1,6-Naphthyridin-2(1H)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022;65(11):7595-7618.
CAS Number
– 2423992-63-4
Molecular Weight
– 663.55
SMILES
– CC#CC(NC1=C(N2[C@H]3C[C@H](OC3)C2)C=C(C(C4=NC=C(C=C(C5=C(C(OC)=CC(OC)=C5Cl)Cl)C(N6CC)=O)C6=C4)=C1)OC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
